![]() have successfully synthesized CIS/ZnS core/shell NCs with a maximum fluorescence quantum yield (QY) of 30% by a developed hot-injection method, where Cu/In stoichiometric ratio in the obtained NCs was controlled by balancing the reactivity of two cationic precursors. As alternatives, I-III-VI NCs such as CuInS 2 (CIS) with a band gap of 1.45 eV have been gaining increased attentions as a promising contrast agent for the in vivo near infrared (NIR) fluorescence imaging, due to advantages of non-toxicity and photoluminescence (PL) emission in NIR region, particularly. Among them, cadmium-contained QDs, including CdSe and CdTe, have been major research topics due to their excellent electrical and optical properties, but the intrinsic toxicity of cadmium limits their applications especially in the biomedical areas. Semiconductor nanocrystals (NCs), or quantum dots (QDs), have attracted immense interests in recent years as a novel class of material due to their special properties and a wide range of potential applications, such as transistors, waveguides, lasers, and biolabels. Keywords: CuInS 2, Near-infrared, In vivo imaging, Blue shift, Tumor Targeting. ![]() The result indicates that the signals detected in the tumor region are much more distinguishing injected with ZCIS/ZnS-cRGD QDs than that injected with ZCIS/ZnS QDs. After confirmation of biocompability by cytotoxicity test on normal 3T3 cells, these QDs are injected via tail vein into nude mice bearing U87 MG tumor. Furthermore, the obtained near infrared (NIR) ZCIS/ZnS QDs are transferred into aqueous phase by a polymer coating technique and coupled with cyclic Arg-Gly-Asp peptide (cRGD) peptides. Namely, both cation exchange inhibition and ions accumulation are involved during the synthesis of ZCIS/ZnS QDs. ![]() Particularly, a hypothesis is proposed and proved for explanation of this effective strategy. The experimental results demonstrate this elaborate facile strategy is effective for the reduction of blue-shift during shell growth. In this strategy, Zn 2+ ions are intentionally employed for the synthesis of alloyed ZCIS core QDs before ZnS shell coating, which contributes to the reduced blue-shift in photoluminescence (PL) emission. File import instruction AbstractĪ facile strategy is reported here for synthesis of Zn-Cu-In-S/ZnS (ZCIS/ZnS) core/shell QDs to address the synthetic issues that the unexpected blue-shift of CuInS 2-based nanocrystals. Select the file that you have just downloaded and select import option Reference Manager (RIS). Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging. Guo W, chen N, Tu Y, Dong C, Zhang B, Hu C, Chang J. ✉ Corresponding author: Tel/Fax: +081821, jinchangedu.cn (Jin Chang) Tel: +088029, Fax: +083706-0, bingbozhangedu.cn (Bingbo Zhang). Imaging Center, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, China. The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, 200092, China.Ĥ. Department of Medical Radioprotection, School of Radiation Medicine and Health, Soochow University, Suzhou, 200072, China.ģ. Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin, 300072, China.Ģ. Weisheng Guo 1, Na chen 2, Yu Tu 2, Chunhong Dong 1, Bingbo Zhang 3,, Chunhong Hu 4, Jin Chang 1,ġ. Research Paper Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging
0 Comments
Leave a Reply. |